NOT KNOWN DETAILS ABOUT SAPLA

The functionality of SIK1 in tumorigenesis. SIK1 is often a tumor suppressor gene, which plays a crucial regulatory role in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and impacts cancer cell proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 may also promote cancer ce